Research Paper Volume 11, Issue 15 pp 5368—5388

Downregulation of microRNA-218 is cardioprotective against cardiac fibrosis and cardiac function impairment in myocardial infarction by binding to MITF

Figure 6. Upregulated MITF expression improves cardiac function in MI rats. (A) the mRNA expression of MITF in cardiac tissues of MI rats detected by RT-qPCR, n = 3; (B) the protein expression of MITF in cardiac tissues of MI rats detected by western blot assay, n = 3; (C) the LVEF and LVFS of rats detected by ultrasonic cardiogram, n = 12; (D) the LVSP, LVEDP, +dp/dt max and -dp/dt max of rats detected by hemodynamic monitoring, n = 12; * versus the sham group, P < 0.05; # versus the MI group, P < 0.05; Data were analyzed by t test or one-way ANOVA. Pairwise comparison after ANOVA was performed by LSD-t. MI, myocardial infarction; LVEF, left ventricular ejection fraction; LVFS, left ventricular fraction shortening; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end diastolic pressure; RT-qPCR, reverse transcription quantitative polymerase chain reaction; MITF, microphthalmia-associated transcription factor.