Research Paper Volume 11, Issue 15 pp 5628—5645

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age

Figure 3. Alk5i+OT treatment improves cognitive performance in aged mice. (A) Schematics of the whisker-dependent texture discrimination task. (B, C) Alk5i+OT treatment does not affect the explorative behavior of aged mice during the encoding phase (B, p=0.659), but significantly improves the performance in texture discrimination (C, p<0.001). (D) Schematics of the NOR test. (E, F) Alk5i+OT treatment does not affect the explorative behavior of aged mice during the encoding phase (E, p=0.864), but significantly enhances their preference to the novel object during the testing phase (C, p<0.001). n = 7 for both tasks. Light grey: individual animal. Black: group average. Error bars: S.E.M. p<0.001.