LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis

Er-lin Song; Li Xing; Liang Wang; Wen-ting Song; Dan-bin Li; Yi Wang; Yi-wei Gu; Ming-ming Liu; Wen-jun Ni; Peng Zhang; Xin Ma; Xu Zhang; Jie Yao; Yang Chen; Rui-hua An

doi:doi:10.18632/aging.102154

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Research Paper Volume 11, Issue 15 pp 5705—5725

LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis

Figure 1. ADAMTS9-AS2 is a lncRNA suggested by its bioinformatics analyses. (A) The chromosomal location and conservation analysis of ADAMTS9-AS2 using UCSC database. (B) Protein-coding potential of ADAMTS9-AS2 predicted by PhyloCSF database. (C) Extended overall survival of patients with high expression of ADAMTS9-AS2 in KIRC. (D) Extended disease free survival of patients with high expression of ADAMTS9-AS2 in KIRC. (E) The expression level of ADAMTS9-AS2 was decreased along with KIRC stage grade increased. ADAMTS9-AS2, ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2; lncRNA, long non-coding RNA; KIRC, kidney renal clear cell carcinoma.