Review Volume 11, Issue 16 pp 6602—6613

Pathophysiology of aged lymphatic vessels

Figure 2. NO–dependent regulatory mechanisms in aged lymphatic vessels. (A) In adult lymphatic vessels, the enhanced eNOS activity mediates the transient inhibition of contraction frequency to adapt the load by the increase of imposed flow. (B) In aged lymphatic vessels, increased iNOS level renders the contractile parameters unchanged in response to increased imposed flow.