Review Volume 11, Issue 16 pp 6602—6613

Pathophysiology of aged lymphatic vessels

Figure 4. Mast cells in peri-lymphatic tissues. (A) Lower level pre-activation of mast cells in adult peri-lymphatic tissues under resting conditions. (B) In aged peri-lymphatic tissues, increased number of mast cells are activated and secret massive amounts of histamine, leading to hyperpermeability of lymphatic vessels.