Research Paper Volume 11, Issue 17 pp 6904—6914

Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults

Figure 2. Prediction of changes in hippocampus volume and cognition by baseline plasma NFL. Associations between baseline plasma NFL concentrations or rate of change in plasma NFL and longitudinal data were tested by LMEMs corrected for age, sex, education and APOE genotype. (A) In CN+ group, higher baseline plasma NFL levels were significantly associated with an increased rate of change in hippocampus volume (β = -0.0351, p = 0.0088). This association did not exist in CN- group (β = -0.0007, p = 0.9311). (B) Results did not show association between baseline plasma NFL levels and ADNI_EF (CN-: β = -0.0076, p = 0.5975; CN+: β = -0.0135, p = 0.5070). (C) In CN+ group, higher baseline plasma NFL levels were significantly associated with an increased rate of change in ADNI_MEM (β = -0.0349, p = 0.0274). This association did not exist in CN- group (β = -0.0009, p = 0.9313).