Research Paper Volume 11, Issue 17 pp 6915—6929

Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

Figure 5. Altered gut bacteria composition at the species level. (A) Relative abundance at the species level. (B) Lactobacillus murinus. (C) Lactobacillus johnsonii. (D) Mucispirillum schaedleri. (E) Candidatus Arthromitus sp. SFB-mouse. (F) Escherichia coli. (G) Blautia sp. Ser8. (H) Robinsoniella peoriensis. (I) Clostridium sp. Clone-27. (J) Blautia sp. canine oral taxon 143. (K) Parabacteroides distasonis. (L) Blautia coccoides. (M) Clostridium sp. HGF2. (N) Clostridium bolteae. (O) Lactobacillus intestinalis. (P) Lactobacillus reuteri. (Q) Bacteroides acidifaciens. (R) [Clostridium] cocleatum. (S) Enterococcus casseliflavus. (T) Bacteroides sp. TP-5. (U) Negative correlation (r = -0.38, P = 0.01) between Lactobacillus intestinalis and DAT immunoreactivity. (V) Negative correlation (r = - 0.39, P = 0.01) between Lactobacillus reuteri and DAT immunoreactivity. Data are shown as mean ± S.E.M. (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001. See the Supplementary Table 3 for detailed statistical analysis.