Research Paper Volume 11, Issue 17 pp 6999—7020

Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment

Figure 4. Survival analysis of significant DEGs in 533 ccRCC from TCGA database. Among 6 significant hub genes, significantly decreased AGPAT9, AQP7, HMGCS2, KLF15, PPARGC1A mRNA expressions were found in ccRCC tissues compared with adjacent normal tissues, while MLXIPL mRNA expression was significantly elevated in tumor samples compared with normal samples. Kaplan-Meier method indicated that decreased AGPAT9, AQP7, HMGCS2, KLF15, PPARGC1A mRNA expression significantly correlated with poor OS (p<0.001), and elevated MLXIPL mRNA expression was significantly associated with shorter OS for ccRCC patients (p=0.012).