Research Paper Volume 11, Issue 17 pp 7123—7149

Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells

Figure 8. CBX8 expression is up-regulated in HCC and is correlated with poor prognosis. (AB) Expression of CBX8 in the TCGA and GSE14520 cohorts (P < 0.001) (C) Expression levels of CBX8 in HCC tissues and adjacent non-tumor tissues (NFYY cohort) as measured by qRT-PCR analysis (P < 0.05); β-actin was used as an internal control. Data are shown as median with interquartile range. (D) The protein expression of CBX8 in 8 HCC samples was determined by western blotting. (E, F) Kaplan-Meier analysis of the overall and disease-free survival in the TCGA cohort based on CBX8 expression (G, H) Kaplan-Meier analysis of the overall and disease-free survival in the TCGA cohort based on CBX8 and YBX1 expression.