Research Paper Volume 11, Issue 18 pp 7416—7441

Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation

Figure 4. OHC count in KI mice. (A) Representative confocal images of OHCs and IHCs at the age of 20 weeks and 60 weeks. Bracket indicates three rows of OHCs, and arrowhead points to one row of IHCs (Scale Bar, 20 μm). (B) Line graphs illustrating the percentage of OHC survival in every cochlear turn of each group and at each time point. There were fewer losses of OHCs in both homozygous and wild-type mice at 20 weeks old (left panel, P>0.05, two-way ANOVA followed by Bonferroni post-test). Both groups had minor OHC loss at the age of 60 weeks, but no difference between the two groups was found (right panel, P>0.05, two-way ANOVA followed by Bonferroni post-test).