Research Paper Volume 11, Issue 17 pp 7242—7256

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions

Figure 4. Acceleration of senescence in several tissues is observed in Idh2 knockout mice. (A) P21 and p53 levels in lung and spleen tissues from wild type and Idh2 knockout mice as determined by immunohistochemistry. Images show p21 and p53 signals. Scale bar, 10 μm (n = 6/group). (B) Statistical analysis of p21 and p53-positive signals between lung and spleen tissues from wild type and Idh2 knockout mice. (C) Representative H&E-stained sections from wild type and Idh2 knockout mouse lungs (n = 6/group). (D) Representative H&E-stained sections from wild type and Idh2 knockout mouse spleens (n = 6/group).