Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 10. Activation of MyD88-NFκB signaling. Expression of MyD88 significantly increased in AD mice compared with WT mice (p<0.05). The increased MyD88 was inhibited in AD-TLR2KO mice compared with AD mice (p<0.05). Expression of pNF-kB significantly increased in AD mice compared with WT mice (p<0.05). The phosphorylation of NF-kB was inhibited in AD-TLR2KO mice compared with AD mice (p<0.05).