Research Paper Volume 11, Issue 17 pp 7257—7273

Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

Figure 4. White matter integrity evaluated by DTI images detected by 7 Tesla MRI system. (A) Representative diffusion-encoded-color (DEC) map and fractional anisotropy (FA) map showing white matter injury (yellow arrow). (B) Quantitative analysis showed that the FA value significantly decreased in TLR2KO mice (&), AD mice (#), and AD-TLR2KO mice (+) compared with WT mice (p<0.05, B). (C) Axial diffusivity (Da) value decreased in AD-TLR2KO mice compared with WT mice (+: p<0.05). (D) Radial diffusivity (Dr) value increased in AD (#) and AD-TLR2KO (+) mice compared with WT mice (p<0.05). (E) There was no significant deference in the mean diffusivity (MD) value among the groups. (n= 4~6 / group).