Research Paper Volume 11, Issue 20 pp 8792—8809

Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD

Figure 5. The promoting effects of over-expressed lncRNA MALAT1 on cardiac remodeling in hypertensive rats is reversed by over-expression of MyoD. (A) the expression of lncRNA MALAT1 in myocardial tissues and thoracic aortic vascular tissues of SHRs, as measured by RT-qPCR; (B) the expression of MyoD in myocardial tissues and thoracic aortic vascular tissues of SHRs measured using Western blot analysis; (C) LVW and LVW/BW ratio of SHRs; (D) Masson staining images of myocardial tissues (scale bar = 50 μm); (E) HE staining images of myocardial tissues (scale bar = 25 μm); (F) pathological changes of thoracic aortic vascular tissues of SHRs, observed by HE staining (× 40); (F) collagen deposition in thoracic aortic vascular tissues of SHRs, observed by Masson staining (× 400); (H) the expression of fibronectin and collagen I in thoracic aortic vascular tissues of SHRs, measured by Western blot analysis; *, p < 0.05 vs. the LV-CON-vector group; #, p < 0.05 vs. the LV-MALAT1 + LV-CON-vector group; measurement data were expressed by means ± standard deviation and analyzed by one-way analysis of variance; n = 6.