Research Paper Volume 11, Issue 18 pp 7537—7552

Hydrogen sulfide is a novel regulator implicated in glucocorticoids-inhibited bone formation

Figure 1. Dexamethasone induced osteoporosis and downregulated serum H2S and mRNA expressions of CBS and CSE in BM SCs. (A) BMD in the distal end of the intact femurs of each experimental group. n=5, **p<0.01. (B) Hematoxylin-eosin staining was performed to identify histological structures of the distal end of the intact femurs of rats injected with Dex for 4 weeks. Scale bars are 50 μm. (C) Representative figures of micro-CT analysis of the distal end of the intact femurs of rats treated with Dex. (D) BV/TV in the distal end of the intact femurs of each experimental group. n=5, **p<0.01. (E) Tb.N in the distal end of the intact femurs of each experimental group. n=5, **p<0.01. (F) Tb.Th in the distal end of the intact femurs of each experimental group. n=5, **p<0.01. (G) Tb.Sp in the distal end of the intact femurs of each experimental group. n=5, **p<0.01. (H) Effects of Dex on serum H2S. n=5, **p<0.01. (IJ) Effects of Dex on mRNA expressions of CBS and CSE in BMSCs. n=5, **p<0.01.