Research Paper Volume 11, Issue 18 pp 7587—7604

Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults

Figure 4. Selected gene transcripts associated with p53/p21 axis of autophagy and the relationship to the PERK arm of the UPR. Gene transcripts associated with p53/p21 axis are elevated at baseline (A) and decreased 18h post-exercise (B) in older compared to younger adults. Correlations between gene transcripts associated with the PERK arm of the UPR and p53/p21 axis post-exercise (C) in young (bottom left) compared to older (upper right) adults. The correlation matrix heat maps demonstrate significant positive (dark red) and negative (dark blue) relationships between the fold-change from baseline to 18h post-exercise for the individual gene transcripts associated with the UPR pathway in young and older adults. *Significantly (p ≤ 0.05) different between groups. Data bars are presented as mean ± SEM.