Research Paper Volume 11, Issue 18 pp 7587—7604

Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults

Figure 5. The relationships between markers of satellite cell differentiation, the p53/p21 axis of autophagy and the PERK arm of the UPR. The fold change from baseline to 18h post-exercise in gene transcripts representing satellite cell differentiation in young and older adults (A). Correlations demonstrate significant positive (dark red) and negative (dark blue) relationships between the fold-change from baseline to 18h post-exercise for the individual gene transcripts associated with the satellite cells differentiation markers (Pax3, Pax7, MyoD, MyoG), the p53/p21 axis, and the PERK arm of the UPR pathway in young and older adults (B). Data bars are presented as mean ± SEM. *Significant correlation (p ≤ 0.05). † Significantly different (p ≤ 0.05) between young and older adults.