Research Paper Volume 11, Issue 18 pp 7639—7662

miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma

Figure 1. miR-125a-5p is down-regulated in HCC tissues and cells. (A) Heat map of differentially expressed miRNAs in eight matched pairs of HCC tissues and adjacent normal tissues. (B) qRT-PCR indicated that miR-125a-5p expression was down-regulated in HCC tissues compared to the adjacent normal tissues. Student’s t-test, mean ± SD, *P<0.05, **P<0.01. (C) miR-125a-5p expression was down-regulated in HCC tumor tissues compared to adjacent normal tissues in TCGA in Starbase. (D) qRT-PCR indicated that miR-125a-5p expression was lower in HCC cell lines (Bel-7404, SK-Hep1, Bel-7404, and MHCC-97H) than in a normal liver cell line (L02). Student’s t-test, mean ± SD, **P<0.01, ***P<0.001. (E) Kaplan-Meier curves indicated that overall survival of HCC patients was not associated with miR-125a-5p expression level in Kaplan Meier Plotter.