Research Paper Volume 11, Issue 18 pp 7830—7846

Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death

Figure 1. The correlation between LncRNA-XIST expression levels and NSCLC development. (A) Real-Time qPCR was used to screen NSCLC associated LncRNAs. (B) Real-Time qPCR was used to detect LncRNA-XIST levels in 30 paired clinical tissues collected from NSCLC patients. (C, D) LncRNA-XIST levels were compared according to lymphatic metastasis (C) and TNM stage. (E) Pan-cancer analysis was conducted to investigate the correlation of LncRNA-XIST levels and prognosis of patients with lung adenocarcinoma. (F) Kaplan-Meier analysis was used to analyse the percent survival of NSCLC patients in our experiments. (J) Real-Time qPCR was used to detect LncRNA-XIST levels in HBE, A549, H1299, SK-MES-1 and Calu-3 cell lines. (“NS” represented no statistical significance, “*” represented p < 0.05, “**” represented p < 0.01).