Research Paper Volume 11, Issue 20 pp 8892—8910

TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway

Figure 7. Effects of LY on radiosensitivity of gastric cancer in vivo. (A and B) Changes in tumor sizes: images of BALB/c nude mice with tumors and resected tumors after LY with or without irradiation treatment. (C) Changes in tumor volumes: the statistical curves of gastric tumor volumes influenced by LY with or without irradiation treatment. (D) Changes in tumor weights: the final tumor weight after LY with or without irradiation treatment for 18 days. (E) TUNEL assays: representative images of the apoptostic cells in GC xenografts influenced by LY with or without irradiation treatment. (F) Changes in genetic expression in GC xenografts: the immunohistochemical analysis of the TGF-β1, TGF-β2, SMAD4, E-CA, N-CA and Ki-67 expressions in GC xenografts influenced by LY with or without irradiation treatment. Original magnification, ×400. *P<0.05, ****P<0.0001.