Research Paper Volume 11, Issue 19 pp 8484—8501

CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma

Figure 1. Differentially expressed circRNAs, miRNAs and mRNAs in pancreatic adenocarcinomas (PAAD). Volcano plots and heatmaps show identification of (A) DEcircRNAs in GSE69362, (B) DEcircRNAs in GSE79634, (C) DEmiRNAs in GSE60980 (GPL15159) and (D) DEmRNAs in GSE60980 (GPL14550) between PAAD tissues and adjacent normal pancreatic tissue. The red color indicates upregulated genes in the PAAD tissues and blue color indicates downregulated genes, while black color indicates genes with no significant differences between the PAAD and normal pancreatic tissues. Heatmaps show the expression patterns of DEcircRNAs, DEmiRNAs and DEmRNAs. The PAAD and adjacent normal pancreatic tissues are represented by red and blue color, respectively. (E) Venn diagrams show commonly upregulated DEcircRNAs and downregulated DEcircRNAs in the PAAD tissues in both GSE69362 and GSE79634. Purple and orange circles indicate the number of DEcircRNAs in the GSE69362 and GSE79634 datasets, respectively. The red circles in the middle indicate the overlapping circRNAs between the two datasets. (F) Venn diagram shows the intersection between DEmiRNA-predicted targets obtained from miRDB, miRTarBase and TargetScan databases and DEmRNAs in GSE60980 (GPL14550).