Research Paper Volume 11, Issue 22 pp 10061—10073

PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades

Figure 4. Effect of pterostilbene treatment combined with Compound C or EX527 on cardiac toxicity and oxidative stress in DOX-exposure mice hearts. (A) Representative images of the ultrastructural morphology of mitochondria from the left ventricular myocardium of experimental mice (magnification: upper panel 9900 ×, lower panel 20,500 ×). (B) ROS level, (C) SOD and (D) GPx activity in the myocardial tissues are showed. The results are expressed as the mean ± SEM. *P < 0.05 vs. the Sham group, #P < 0.05 vs. the DOX-treated group, $P < 0.05 vs. the DOX+PTS cotreated group.