Research Paper Volume 11, Issue 21 pp 9738—9766

Selected by gene co-expression network and molecular docking analyses, ENMD-2076 is highly effective in glioblastoma-bearing rats

Figure 4. (A) ENMD-2076 chemical structure from virtual screening. (B) 2D inter-molecular interaction diagram of ENMD-2076 Aurora kinase A complex. (C) The Ramachandran diagrams of Aurora kinase A. (D) Schematic drawing of interactions between Aurora kinase A and ENMD-2076. (E) Average backbone root mean square deviations (RMSD) curve of ENMD-2076 Aurora kinase A complex. (FG) Potential energy profiles of ENMD-2076 Aurora kinase A complex performed by molecular dynamic simulation.