Figure 6. HIF1A-AS2 regulates cell proliferation, cell cycle progression and invasion of osteosarcoma cells through the modulation of miR-129-5p. (A) The cell proliferation of MG-63 cells was determined by MTT analysis. (B) Ectopic expression of miR-129-5p decreased the S phase of HIF1A-AS2-overexpressing MG-63 cells compared to that of the scrambled group. (C) Elevated expression of miR-129-5p suppressed the invasion of HIF1A-AS2-overexpressing MG-63 cells compared to the invasion of the scrambled group. (D) The relative invasive cells are shown. *p<0.05, **p<0.01 and ***p<0.001.