Research Paper Volume 11, Issue 24 pp 11865—11879

MicroRNA 27b promotes cardiac fibrosis by targeting the FBW7/Snail pathway

Figure 2. miR-27b expression promoted cardiac fibrosis (AC) Supplementation of antagomiR-27b (miR-27i) inhibited the CF proliferation in neonatal rats. (A) Counting of cell numbers. (B) MTT analysis. (C) BrdU assay. (D) Collagen I, III, and MMP-9 mRNA levels in CFs treated with AngII in combination with miR27i. (E, F) Supplementation of miR-27b stimulated the proliferation of neonatal rats CF. (E) MTT test. (F) BrdU assay. (G) Collagen I, III, and MMP-9 mRNA levels in miR-27b-treated CFs. Data were represented as mean ± SEM (n=4). *, p<0.05; **, p<0.01.