Research Paper Volume 11, Issue 24 pp 11905—11921

KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway

Figure 1. KIF20A is dysregulated in CRC according to online database information. (A) The overlap of the dysregulated genes from GSE10972, GSE18105 and GSE41657 using GRO2R online analysis. Screen standard: P value < 0.05, fold change > 1.5. (B) Protein-protein interaction network analysis of 338 overlap genes. Red color represents upregulated genes. Green color represents downregulated genes. Size of the circle reflects the expression fold change of genes. (C) Enriched pathway analysis, biological process and molecular function analysis of 338 overlap genes. (D) Analysis of the expression pattern of KIF20A in normal colorectal tissue, colon adenoma and CRC based on the data from GSE20916. (E) Analysis of the expression pattern of KIF20A in normal colorectal tissue and different types of intestinal cancers based on the data from TCGA.