Research Paper Volume 11, Issue 24 pp 11955—11974

Platelet-derived β2m regulates age related monocyte/macrophage functions

Figure 2. Monocytes from Plt-β2M-/- mice had a more reparative gene expression pattern. (A) Circulating monocytes from aged WT, but not Plt-β2M-/- mice, had increased inflammatory gene expression. Peripheral blood monocytes were isolated and qRT-PCR for inflammatory associated gene markers, Fcgr1, Cxcl1, Nos2 performed (N=3, mean ± SD, **P<0.01, one-way ANOVA with Bonferroni correction). (B) Monocytes from aged Plt-β2M-/- mice had increased reparative associated gene expression compared to WT mice. Peripheral blood monocytes were isolated and qRT-PCR for Il10, Il27, Cxcl12 performed (N=3, mean ± SD, **P<0.01, one-way ANOVA with Bonferroni correction).