Research Paper Volume 11, Issue 24 pp 12057—12079

Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients

Figure 5. Transcriptional expression of CCND1 and PECAM1/CD31 in ccRCC tumor tissues and adjacent normal renal tissues. (A) Transcriptional level of CCND1 expression was found highly expressed in 533 ccRCC tissues compared with 72 normal tissues (p<0.0001). (B) Transcriptional expression of CCND1 was significantly correlated with AJCC stages, patients who were in more mild stages tended to express higher mRNA expression of CCND1. (C) Transcriptional expression of CCND1 was significantly correlated with ISUP grade, patients who were in more mild grade score tended to express elevated mRNA exspression of CCND1. Highest mRNA expressions of CCND1 were found in stage 1 or grade 1. (D) Transcriptional level of PECAM1/CD31 expression was found highly expressed in 533 ccRCC tissues compared with 72 normal tissues (p<0.0001). (E) Transcriptional expression of PECAM1/CD31 was significantly correlated with AJCC stages, patients who were in more mild stages tended to express higher mRNA expression of PECAM1/CD31. (F) Transcriptional expression of PECAM1/CD31 was significantly correlated with ISUP grade, patients who were in more mild grade score tended to express elevated mRNA expression of PECAM1/CD31. Highest mRNA expressions of PECAM1/CD31 were found in stage 1 or grade 1.