Figure 8. Significant related genes and hallmarks pathways in ccRCC obtained by GSEA. A total of 100 significant genes were obtained by GSEA with positive and negative correlation. (A–E) The most involved significant pathways included hedgehog signaling, heme metabolism, PI3K/AKT/MTOOR signaling, TGF-β signaling, UV-response, and WNT/β/CATEMIN signaling. (F) Transcriptional expression profiles of the 100 significant genes were performed in a heat map.