Research Paper Volume 11, Issue 24 pp 12147—12164

Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p

Figure 4. The effects of hematoma-derived exosomes on angiogenic cytokine expression. (A) Representative images of the cytokine array. (B) Quantification of cytokine expression. ANG-2, EGF, Endoglin, and CXCL4 expression were higher in the EX-Hematoma compared to the EX-Serum group. (CE) RT-PCR analysis of ANG-1, ANG-2, and Tie-2 mRNA expression following co-culture with exosomes. ANG-2 mRNA expression was higher, while ANG-1 expression was lower in the EX-Hematoma compared to the EX-Serum group. * p < 0.05, *** p < 0.001.