Research Paper Volume 11, Issue 23 pp 11659—11672

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

Figure 7. Schematic diagram of the possible inflammatory response induced by NiCl2. NiCl2 triggers the transcription of pro-inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-18, TNF-α and INF-β through the NF-κB, MAPKs, IRF3 signaling pathways in the BMDM. And NiCl2 also can induce caspase-1 activation via NRLP3 inflammasome activation. Moreover, NiCl2 induces apoptosis through mitochondrial ROS-mediated pathway, and also, NLRP3 inflammasome activation contributes to the apoptosis.