Research Paper Volume 11, Issue 24 pp 12328—12344

Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis

Figure 7. Overexpressed METTL1 promoted CR-CC cells apoptosis by regulating S100A4. (A, B) FCM was conducted to determine cell apoptosis ratio in CC cells. (C, D) Western Blot was employed to detect the expression levels of cleaved Caspase-3 in CR-CC cells. (“Con” represented “Control group”, “Cis” indicated “Cisplatin treated group”, “Cis+OE-MET” represented “Cisplatin plus overexpressed METTL1 treated group”, “Cis+OE-M+OE-S” represented “Cisplatin plus overexpressed METTL1 and overexpressed S100A4 treated group”). “*” means p < 0.05, “**” means p < 0.01 and “NS” means no statistical significance.