Research Paper Volume 11, Issue 24 pp 12345—12360

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

Figure 2. CircSMO742 and miR-338-3p had an opposite expression in glioma. (A) The mosaic site sequence information of circSMO742. (B) Higher expression level of circSMO742 in tumor tissue than in non-tumor tissues in 10 tumor samples, P<0.05. (C) Higher level of circSMO742 expression in A172 and U-87 MG, measured with qRT-PCR. (D) RNase eliminated the SMO mRNA. (E) Negative correlation of miR-338-3p and circSMO742 in 10 tumor tissues, R2=0.5505, P<0.05. (F) lower level of miR-338-3p expression in A172 and U-87 MG, measured with qRT-PCR. (G) CircSMO742 was located in the cytoplasm. (H) Lower expression level of SMO proteins in A172 and U-87 MG, detected with western blot assay. *P<0.05, **P<0.01, ***P<0.001, v.s. HA; #P<0.05, ##P<0.01, ###P<0.001, v.s. SVGP12.