Research Paper Volume 11, Issue 24 pp 12428—12451

System level characterization of small molecule drugs and their affected long noncoding RNAs

Figure 4. Pharmacological properties of connected drug pairs in the SSN. (A, left) 417 drug pairs with the same lncRNAs shared the same indications, compared with 1000 permutations. (A, right) Acetohexamide and gliclazide were connected to the same lncRNAs and they were all used for the treatment of diabetes. (B, left) 1066 drug pairs with the same lncRNAs shared the same drug targets, compared with 1000 permutations. (B, right) Minaprine and thioridazine shared the same lncRNA and both target the serotonin receptor 2A (HTR2A). (C, left) The proportion of shared side effects by drug pairs with the same lncRNAs (red), compared with the proportion of shared side effects among the total drug pairs in the SIDER database (blue). (C, right) Atovaquone and galantamine shared the same lncRNAs, although they belong to different categories, and could cause many of the same side effects. (D) Drug pairs with the same lncRNAs had higher TC scores.