Research Paper Volume 11, Issue 24 pp 12641—12660

Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair

Figure 5. MIF overexpression enhanced cell survival and angiogenesis in the rat heart after MI. (A) Representative images of HNA staining and quantitative analysis of MSC survival in the heart tissue of rats in the different groups at 28 days. Scale bar=50 μm. (B) Representative images of α-SMA staining in the heart tissue of rats from the different groups at 28 days. Scale bar=100 μm. (C) Quantitative analysis of the α-SMA density in the heart tissue of rats from the different groups at 28 days. (D) Representative images of CD31 staining in the heart tissue of rats from the different groups at 28 days. Scale bar=100 μm. (E) Quantitative analysis of the CD31 density in the heart tissue of rats from the different groups at 28 days. Data are expressed as the mean±SEM. n=6-7. **p<0.01; ***p<0.001.