Research Paper Volume 11, Issue 24 pp 12685—12707

Combination of lymphocyte number and function in evaluating host immunity

Figure 5. The number and function of lymphocytes in different disease models. (A) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with hypoproteinemia (n=58), diabetes (n=40), lung cancer (n=37), post-chemotherapy (n=32), uremia (n=33), kidney transplantation (n=61), hepatic failure (n=49), liver transplantation (n=33), and matched healthy controls. (B) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with SLE (n=33), RA (n=30), MCTD (n=31), UC (n=31), SS (n=30), AIH (n=30), and matched healthy controls. (C) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with aspergillus infection (n=22), HPV infection (n=38), TP infection (n=34), HIV infection (n=19), PC infection (n=31), CN infection (n=11), and matched healthy controls. Horizontal lines indicate the median. *P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney U-test). SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; MCTD, mixed connective tissue diseases; UC, ulcerative colitis; SS, Sjögren syndrome; AIH, autoimmune hepatitis; HPV, human papillomavirus; TP, Treponema pallidum; HIV, human immunodeficiency virus; PC, Pneumocystis carinii; CN, Cryptococcus neoformans.