Research Paper Volume 12, Issue 1 pp 690—706

Dysregulation of antimicrobial peptide expression distinguishes Alzheimer’s disease from normal aging

Figure 1. Comparison of innate immunity gene expression variances in WT flies with age among GEO datasets. The occurrence of high expression was introduced as a statistical parameter to compare the relative expression quantity of immune-related genes across age groups. The upper figures exhibit the rate differences among different classes of genes associated with innate immunity between the middle-aged and young (A), old and middle-aged (B), and old and young (C) groups, clearly demonstrating that AMPs had the most significant differential expression. The expression levels of other gene clusters were generally unchanged. Transcriptional differences in AMP genes were subsequently compared using meta-analysis. The odds ratio between the middle-aged and young (D), old and middle-aged (E), and old and young (F) groups, are shown in the lower graphs, indicating an increased expression of AMPs in the head of WT Drosophila during aging.