Research Paper Volume 12, Issue 1 pp 690—706

Dysregulation of antimicrobial peptide expression distinguishes Alzheimer’s disease from normal aging


Figure 2. RNA-seq analysis of differentially expressed genes associated with the innate immune system in control and AD Drosophila model. There were significant differences in transcriptional levels of AMPs and LysS between the two groups. The line chart (A) illustrates different expression patterns of differentially expressed immune-related genes between WT (red, round dots) and AD (blue, square dots) groups during aging. The box plot (B) presents differences in expression therein between the normal (red, left) and disease (blue, right) groups at each time point (3-, 10-, 20-, 30-days post eclosion).