Research Paper Volume 12, Issue 2 pp 1304—1321

AURKB promotes gastric cancer progression via activation of CCND1 expression

Figure 7. Expression of AURKB and CCND1 is upregulated in gastric cancer tissues, and these expression levels are associated with poor prognosis in gastric cancer patients. (A) Representative images of immunohistochemical (IHC) staining of AURKB and CCND1 in human gastric cancer tissues and matched normal tissues (n = 80). (B) Total IHC score for AURKB and CCND1 in human gastric cancer tissues (Tumor) and matched normal tissues (Normal). **P < 0.01 compared with the matched normal tissue control. (C) The correlation between AURKB and CCND1 expression was evaluated using Pearson correlation analysis (n = 80; r = 0.5764; P < 0.01). D, Analysis of data from the Kaplan-Meier plotter database suggested that high expression levels of AURKB (left panel; P = 0.0012) and CCND1 (right panel; P = 0.0026) are negatively correlated with 5-year overall survival in gastric cancer patients.