Research Paper Volume 12, Issue 3 pp 2123—2131

Bone morphogenetic protein 9, and its genetic variants contribute to susceptibility of idiopathic pulmonary arterial hypertension

Figure 3. BMP9 rs7923671 and rs3740297 affect luciferase activities in PASMC cells. (A) relative luciferase activities of rs7923671 were measured in PASMC cells. (B) SNP-miRNA duplex for rs3740297 and miR-149. (C) relative luciferase activities of rs3740297 were measured in PASMC cells transfected with C allele, or T allele. Cells in different groups were treated with blank control, miR-149 mimic or antagomir-miR-149. Three replicates for each group and the experiment were repeated three times.