Research Paper Volume 12, Issue 4 pp 3574—3593

SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway

Figure 5. Immunohistochemical analysis of SERPINH1 protein expression in human GC tissues. (A) Immunohistochemical (IHC) analysis shows that SERPINH1 protein levels are significantly higher in five pairs of matched GC tissues compared with the adjacent non-tumor gastric mucosal tissues. (BE) Representative images show IHC staining of SERPINH1 protein in (B, C) normal gastric mucosal tissues and (D, E) gastric cancer tissues at 100X and 200X magnification, respectively. (F) Comparison of IHC scores show that SERPINH1 protein expression is significantly higher (P=0.02) in gastric cancer tissues (N=102) compared with adjacent non-tumor gastric tissues (N=48). (G) Survival curve analysis shows that GC patients with high SERPINH1 protein levels exhibit poorer OS than patients with low SERPINH1 protein levels (HR=3.35, P=0.0004).