Research Paper Volume 12, Issue 5 pp 4379—4393

Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease

Figure 3. Distribution and representative mass spectra of the genetic markers in the study. (A) The 38 polymorphisms within RET, ARHGEF3 and CTNNAL1. Blue lines denote the studied SNPs; Purple lines and arrows represent the exons in the genomic region; (B) Representative mass spectra of the 14 genetic variants within RET. Blue dotted lines denote the presence of the studied alleles; Red dotted lines indicate no allele detected; Grey dotted lines represent the unrelated peaks. SNP = single nucleotide polymorphism.