Research Paper Volume 12, Issue 5 pp 4506—4526

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Figure 1. Effects of lncRNA GUSBP5-AS on the treatment of DVT. (A) Representative images of the thrombosis in GFP-GUSBP5-AS-EPC group and LV5-NC group were observed. (B) Weight of the venous thrombi at day 7 after the transplantation. Data are expressed as mean ± SEM (n = 8 mice per group), **P < .01 compared to the corresponding negative controls. (C) Representative images of recruitment of GFP-positive EPCs in DVT (×200). (D) Percentage of green fluorescent area in DVT. **P < .01. (E) The expression levels of CD34 and MMP2 in thrombosis were detected by immunofluorescence.