Research Paper Volume 12, Issue 5 pp 4506—4526

LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway

Figure 7. The relationship between GUSBP5-AS, miR-223-3p and FOXO1 expression. (AC) Spearman rank correlation analyses showed negative correlation with GUSBP5-AS and miR-223-3p in 15 cases of EPCs samples from DVT patients, and FOXO1 was negatively correlated with miR-223-3p expression, while GUSBP5-AS was positively correlated with FOXO1 expression. (D) miR-223-3p mimics and inhibitor, respectively, inhibited and enhanced the expression of GUSBP5-AS in EPCs. (E) GUSBP5-AS knockdown and overexpression, respectively, reduced and increased the mRNA expression levels of FOXO1 in EPCs. *P < .05, **P < .01 compared to the corresponding control group. Data are represented as mean ± SEM.