Research Paper Advance Articles

Inhibition of miR-19a partially reversed the resistance of colorectal cancer to oxaliplatin via PTEN/PI3K/AKT pathway

Figure 4. Effect of PTEN on regulating the oxaliplatin sensitivity of CRC cells. (A) Transfection with siRNA-PTEN (50 pmol/ml) decreased the expression of PTEN in SW480 and HT29 cells. (B) Transfection with siRNA-PTEN (50 pmol/ml) decreased the sensitivity of SW480 and HT29 cells to oxaliplatin (10 μM) treatment. *P<0.05. (C) Transfection with plasmid-PTEN (2 μg/ml) increased the expression of PTEN in SW480/R and HT29/R cells. (D) Transfection with plasmid-PTEN (2 μg/ml) increased the sensitivity of SW480/R and HT29/R cells to oxaliplatin (10 μM) treatment. *P<0.05.