Research Paper Volume 12, Issue 8 pp 6611—6629

Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis

Figure 8. Mechanism diagram. HO-1 up-regulates Gas6 to mediate the sensitivity of myeloma cells to bortezomib via activating ERK/STAT3 signaling pathway.