Research Paper Volume 12, Issue 7 pp 6067—6088

Identification of an exosomal long non-coding RNAs panel for predicting recurrence risk in patients with colorectal cancer

Figure 5. Construction and performance of exolncRNAs signature in the training set. (A) Risk scores of 5-exolncRNAs were higher in CRC recurrence group than in nonrecurrence group; Data represents the median (interquartile range); [Mann–Whitney U test]. (B) ROC curve for discriminating CRC patients with recurrence from those without recurrence based on AF079515, CCAT1, UCA1, RP11-434B12.1 and HOTTIP alone and in combination. (C) Heatmap of each lncRNA expressed in CRC patients classified into high- and low-risk groups using 5-exolncRNAs, with yellow indicating higher expression and blue indicating lower expression. (D) Kaplan-Meier curves for RFS stratified by 5-exolncRNAs panel in high and low risk using optimal cutoff value (3.998); [log-rank test]. (E) Kaplan-Meier curves for OS stratified by 5-exolncRNAs panel in high and low risk using optimal cutoff value (3.998); [log-rank test].