Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Valérie Fontaine; Elodie Monteiro; Mylène Fournié; Elena Brazhnikova; Thinhinane Boumedine; Cécile Vidal; Christine Balducci; Louis Guibout; Mathilde Latil; Pierre J. Dilda; Stanislas Veillet; José-Alain Sahel; René Lafont; Serge Camelo

doi:doi:10.18632/aging.103014

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Research Paper Volume 12, Issue 7 pp 6151—6171

Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Figure 2. Kinetics of loss of amplitude of scotopic A and B waves and photopic B wave, of A2E accumulation and of loss of photoreceptor nuclear layers in Abca4^-/- Rdh8^-/- mice aged between 2 and 18 months. (A) Scotopic A wave recorded at a flash intensity of 10 cd.s/m² (n = 30-50). (B) Scotopic B wave recorded at a flash intensity of 10 cd.s/m² (n = 30-50). (C) Photopic B wave recorded at a flash intensity of 30 cd.s/m² (n = 30-50). (D) Kinetics of loss of photoreceptor nuclear layers (n = 7-14). (E) Kinetics of A2E accumulation (n = 15-40). Bars represent mean ± s.e.m. *p<0.05, **p<0.01, ***p<0.001, ***p<0.0001 (One-way ANOVA, Dunnett's post-test).