Research Paper Volume 12, Issue 8 pp 6680—6699

Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p

Figure 7. LINC00324 inhibited tumor growth in nude mice xenograft models. (A) Dissection of tumors from non-obese diabetic (NOD) mice xenografted with agomiR-10b-5p alone or combined with overexpressed-LINC00324 MDA-MB-231 cells. (B) Tumor volume curve of overexpressed-LINC00324 and agomiR-10b-5p treatment groups were measured and analyzed. (C) Hematoxylin and eosin-stained images of breast cancer tissues from NOD mice xenografted with agomiR-10b-5p alone or combined with overexpressed-LINC00324 MDA-MB-231 cells. (D) Immunohistochemical staining of E-cadherin expression in breast cancer tissues from NOD mice xenografted with agomiR-10b-5p alone or combined with overexpressed-LINC00324 MDA-MB-231 cells. (EG) Relative expression of miR-10b-5p, LINC00324, and CDH1 in breast cancer tissues from NOD mice xenografted with agomiR-10b-5p alone or combined with overexpressed-LINC00324 MDA-MB-231 cells. All data are shown as means ± SEM. ** P < 0.01, *** P < 0.001. Data are from three independent experiments (B, EG), or are representative of three independent experiments with similar results (A, C, D).