Research Paper Volume 12, Issue 7 pp 6260—6275

Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin

Figure 4. DM1-derived blood samples also show mitochondria dysfunction. mRNA levels of SIRT1, OPA1 and TFAM in PBMCs derived from DM1 (n≥12) and controls (n=4).